High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice

Background Mycobacterium ulcerans is the causative agent of a debilitating skin and soft tissue infection known as Buruli ulcer (BU). There is no vaccine against BU. The purpose of this study was to investigate the vaccine potential of two previously described immunogenic M. ulcerans proteins, MUL_3...

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Opis bibliograficzny

Główni autorzy:	Kirstie M. Mangas, Nicholas J. Tobias, Estelle Marion, Jérémie Babonneau, Laurent Marsollier, Jessica L. Porter, Sacha J. Pidot, Chinn Yi Wong, David C. Jackson, Brendon Y. Chua, Timothy P. Stinear
Format:	Artigo
Język:	Inglês
Wydane:	PeerJ Inc. 2020-08-01
Seria:	PeerJ
Hasła przedmiotowe:	Mycobacterium ulcerans Buruli ulcer Vaccination Mycobacterium Subunit vaccine ELISA
Dostęp online:	https://peerj.com/articles/9659.pdf
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