MSC administration resolves experimental acute gout increasing specialized pro-resolving mediators synthesis through a super-induction of prostaglandin E2

Abstract Background The resolution of inflammation is an active process triggered in the acute phase of inflammation and mainly directed by specialized pro-resolving mediators (SPMs). Modulating the inflammatory response in favor of resolution is a therapeutic strategy of enormous interest and value...

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Main Authors:	Ismael Bermejo-Álvarez, Cristina Vázquez, Alberto Irigaray-Moreno, Ignacio Quevedo-Romero, Aránzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
Format:	Artigo
Language:	Inglês
Published:	BMC 2025-12-01
Series:	Stem Cell Research & Therapy
Subjects:	Specialized-pro-resolving mediators (SPMs) Resolution Acute inflammation PGE2 COX-2 Macrophages
Online Access:	https://doi.org/10.1186/s13287-025-04877-3
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