Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy
We recently reported that depletion of FANCM in ALT cells induces replication stress mainly at their telomeres. Additionally, we found that co-depletion of FANCM and BLM, or FANCM and BRCA1 induces synthetic lethality in the ALT cells. Our new findings could have important implications for cancer pr...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis Group
2017-11-01
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| Serie: | Molecular & Cellular Oncology |
| Soggetti: | |
| Accesso online: | http://dx.doi.org/10.1080/23723556.2017.1360978 |
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