Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer’s Disease

We developed a new method to isolate small extracellular vesicles (sEVs) from male and female wild-type and 5xFAD mouse brains to investigate the sex-specific functions of sEVs in Alzheimer’s disease (AD). A mass spectrometric analysis revealed that sEVs contained proteins critical for EV formation...

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Autori principali:	Ahmed Elsherbini, Zhihui Zhu, Zainuddin Quadri, Simone M. Crivelli, Xiaojia Ren, Hemendra J. Vekaria, Priyanka Tripathi, Liping Zhang, Wenbo Zhi, Erhard Bieberich
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-06-01
Serie:	Cells
Soggetti:	extracellular vesicles Alzheimer’s acid sphingomyelinase ceramide neurotoxicity
Accesso online:	https://www.mdpi.com/2073-4409/12/12/1623
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