Estrogen rescues muscle regeneration impaired by DUX4 in a humanized xenograft mouse model

Abstract Facioscapulohumeral dystrophy (FSHD) is an autosomal dominant muscular dystrophy and one of the most frequent hereditary myopathies. The pathology shows a wide range of clinical signs, with modifying factors contributing to this variability, especially in patients with mild disease. Among t...

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Ngā kaituhi matua:	Silvia Maiullari, Giada Mele, Patrizia Calandra, Giorgia di Blasio, Sonia Valentini, Alessio Torcinaro, Isabella Manni, Emanuela Teveroni, Fabio Mancino, Luca Proietti, Fabio Maiullari, Maria Pesavento, Ludovica Giorgini, Sabrina Putti, Roberto Rizzi, Sara Bortolani, Ferdinando Scavizzi, Marcello Raspa, Enzo Ricci, Giulia Piaggio, Cesare Gargioli, Alfredo Pontecorvi, Siro Luvisetto, Massimiliano Mazzone, Giancarlo Deidda, Fabiola Moretti
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Publishing Group 2025-07-01
Rangatū:	Cell Death and Disease
Urunga tuihono:	https://doi.org/10.1038/s41419-025-07827-2
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!