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Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

Pregnane X receptor (PXR) which belongs to the nuclear hormone receptor superfamily plays vital roles in several biological functions, especially in the inflammatory procedure. Besides that, PXR is revealed by recent studies to have essential effects on bone tissue. As an agonist of PXR, meclizine i...

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Principais autores: Jiachao Guo, Weijin Li, Yingxing Wu, Xingzhi Jing, Junming Huang, Jiaming Zhang, Wei Xiang, Ranyue Ren, Zhengtao Lv, Jun Xiao, Fengjing Guo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017-10-01
Serier:Frontiers in Pharmacology
Fag:
meclizine
PXR
osteoclast
RANKL
osteoporosis
Online adgang:http://journal.frontiersin.org/article/10.3389/fphar.2017.00693/full
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