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Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression

Alterations in the tumor microenvironment are closely associated with the metabolic phenotype of tumor cells. Cancer-associated fibroblasts (CAFs) play a pivotal role in tumor growth and metastasis. Existing studies have suggested that lactate produced by tumor cells can activate CAFs, yet the preci...

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Príomhchruthaitheoirí: Xuyu Gu, Yifei Zhu, Jincheng Su, Sheng Wang, Xiangyu Su, Xu Ding, Lei Jiang, Xiang Fei, Wentian Zhang
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2024-08-01
Sraith:Redox Biology
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Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2213231724001873
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