Comprehensive analysis of heterogeneity and cell-cell interactions in Crohn’s disease reveals novel location-specific insights

Introduction: In Crohn’s disease (CD), lesions are mainly distributed in a segmental manner, with the primary sites of involvement being the ileum and colon. Heterogeneity in colon and ileum results in location-specific clinical presentations and therapeutic responses. Mucosal healing tends to be mo...

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Detalhes bibliográficos

Principais autores:	Jing Feng, Li-Na He, Ruchen Yao, Yuqi Qiao, Tian Yang, Zhe Cui, Xiangjun Meng, Jinlu Tong, Keyu Jia, Zhixiang Zuo, Jun Shen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-10-01
coleção:	Journal of Advanced Research
Assuntos:	Single-cell RNA sequencing Inflammatory bowel disease Crohn’s disease Disease location Heterogeneity
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2090123224006209
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