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Deleting Titin’s C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle

The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle. To study the functional and structural repercussions of a small reduction in the size of the PEVK region, we investigated skeletal muscles of a mouse...

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Principais autores: Robbert J. van der Pijl, Brian Hudson, Tomotaroh Granzier-Nakajima, Frank Li, Anne M. Knottnerus, John Smith, Charles S. Chung, Michael Gotthardt, Henk L. Granzier, Coen A. C. Ottenheijm
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-05-01
coleção:Frontiers in Physiology
Assuntos:
passive tension
titin
PEVK region
hypertrophy
RNA splicing
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphys.2020.00494/full
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