Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle
Abstract Muscle wasting is a major cause of morbidity in the elderly. Ku80 is required for DNA double strand repair and is implicated in telomere maintenance. Complete loss‐of‐function leads to reduced post‐natal growth and severe progeria in mice. We examined the role of Ku80 in age‐related skeleta...
Zapisane w:
| Główni autorzy: | , , , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Springer Nature
2012-08-01
|
| Seria: | EMBO Molecular Medicine |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1002/emmm.201101075 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|