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T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration

Abstract Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding diseases characterized by progressive photoreceptor loss. IRD pathology has been linked to an excessive activation of cyclic nucleotide-gated channels (CNGC) leading to Na+- and Ca2+-influx, subsequent a...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jie Yan, Lan Wang, Qian-Lu Yang, Qian-Xi Yang, Xinyi He, Yujie Dong, Zhulin Hu, Mathias W. Seeliger, Kangwei Jiao, François Paquet-Durand
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2024-02-01
Schriftenreihe:Cell Communication and Signaling
Schlagworte:
Retinitis pigmentosa
Calcium channels
cGMP
HDAC
PAR
SOCE
Online-Zugang:https://doi.org/10.1186/s12964-023-01391-y
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