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IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis

Abstract Background Patients with rheumatoid arthritis (RA) have increased levels of interleukin-18 (IL-18) and decreased levels of IL-18 binding protein (IL-18BP) in the serum and synovial fluid (SF) compared to those in patients with osteoarthritis (OA) or in healthy controls. In this study, we ev...

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Autori principali: Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2021-09-01
Serie:Journal of Translational Medicine
Soggetti:
Interleukin-18 binding protein
Rheumatoid arthritis
Osteoclastogenesis
Type 17 helper T cell
Regulatory T cell
Accesso online:https://doi.org/10.1186/s12967-021-03071-2
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