Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats.
The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats.Six healthy cats (4.9 ± 0.7 kg) were included in a prospective, randomized, blinded, crossover study. Si...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2017-01-01
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| Serie: | PLoS ONE |
| Accesso online: | http://europepmc.org/articles/PMC5405979?pdf=render |
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