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Flexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions

<p>Abstract</p> <p>Background</p> <p>The HIV-1 protease is initially synthesized as part of the Gag-Pol polyprotein in the infected cell. Protease autoprocessing, by which the protease domain embedded in the precursor catalyzes essential cleavage reactions, leads to liberation of the free mature pro...

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Principais autores: Chen Chaoping, Li Yanfei, Huang Liangqun
Format: Artigo
Jezik:Inglês
Izdano: BMC 2011-10-01
Serija:Retrovirology
Online dostop:http://www.retrovirology.com/content/8/1/79
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