Aldehyde Phenylamino-Pyrimidine as Key Precursor for the Synthesis of Imatinib Analogs and In Silico Studies of Their Intermediates

The synthesis of aldehyde-PAP as a key precursor through a triple reaction sequence: diazotization-addition/CuAAC/oxidation by using 4-methyl-<i>N</i>³-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine as the starting material is described. Furthermore, a molecular docking study was con...

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Autors principals:	Luz E. Tierrablanca-Arias, Hugo Cervantes-Valencia, Mitzi N. Piña-Gordillo, Luis Chacón-García, Abel Suárez-Castro, Carlos J. Cortes-García
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-11-01
Col·lecció:	Chemistry Proceedings
Matèries:	Imatinib analogs phenylamino-pyrimidine molecular docking 1,2,3,-triazoles
Accés en línia:	https://www.mdpi.com/2673-4583/14/1/46
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