NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane
Among the RAS isoforms, NRAS uniquely requires carboxyl methylation by ICMT for delivery to the plasma membrane because of having only a single palmitoylation as a second targeting signal. Isoprenylcysteine carboxyl methyltransferase (ICMT) is the third of three enzymes that sequentially modify the...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Life Science Alliance LLC
2021-05-01
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| Edice: | Life Science Alliance |
| On-line přístup: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202000972 |
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