A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling

Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and improves motility.

Dettagli Bibliografici

Autori principali:	Hae-Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Ozlem Altintas, Sangsoon Park, Heehwa G. Son, Yujin Lee, Dongyeop Lee, Won Do Heo, Seung-Jae V. Lee
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2021-09-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-021-25920-w
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