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Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile

ABSTRACT Clostridioides difficile remains a key cause of healthcare-associated infection, with multidrug-resistant (MDR) lineages causing high-mortality (≥20%) outbreaks. Cephalosporin treatment is a long-established risk factor, and antimicrobial stewardship is a key control. A mechanism underlying...

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Sábháilte in:
Príomhchruthaitheoirí: Kate E. Dingle, Jane Freeman, Xavier Didelot, T. Phuong Quan, David W. Eyre, Jeremy Swann, William D. Spittal, Emma V. Clark, Keith A. Jolley, A. Sarah Walker, Mark H. Wilcox, Derrick W. Crook
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: American Society for Microbiology 2023-04-01
Sraith:mBio
Ábhair:
AMR mechanism
antimicrobial resistance
Clostridioides difficile
PBPs
penicillin binding proteins
cell wall transpeptidase
Rochtain ar líne:https://journals.asm.org/doi/10.1128/mbio.00243-23
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