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Accuracy of high-risk HPV DNA PCR, p16(INK4a) immunohistochemistry or the combination of both to diagnose HPV-driven oropharyngeal cancer

Abstract Background The incidence of high-risk human papillomavirus (hrHPV)-driven head and neck squamous cell carcinoma, in particular oropharyngeal cancers (OPC), is increasing in high-resource countries. Patients with HPV-induced cancer respond better to treatment and consequently have lower case...

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Principais autores: Cindy Simoens, Tarik Gheit, Ruediger Ridder, Ivana Gorbaslieva, Dana Holzinger, Eric Lucas, Susanne Rehm, Peter Vermeulen, Martin Lammens, Olivier M. Vanderveken, Rekha Vijay Kumar, Nitin Gangane, Alessandro Caniglia, Fausto Maffini, Maria Belén Lloveras Rubio, Devasena Anantharaman, Susanna Chiocca, Paul Brennan, Madhavan Radhakrishna Pillai, Rengaswamy Sankaranarayanan, Johannes Bogers, Michael Pawlita, Massimo Tommasino, Marc Arbyn, the HPV-AHEAD study group
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-08-01
coleção:BMC Infectious Diseases
Assuntos:
HPV DNA PCR
p16(INK4a) IHC
HPV mRNA
Oropharyngeal carcinoma
HPV-AHEAD
Acesso em linha:https://doi.org/10.1186/s12879-022-07654-2
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