Acetaminophen impairs ferroptosis in the hippocampus of septic mice by regulating glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways

Abstract Background Neuronal ferroptosis is a major cause of cognitive impairment and mortality in patients with sepsis‐associated encephalopathy (SAE). A low dose of acetaminophen (APAP) in septic mice can prevent ferroptosis in the hippocampal tissue; however, the underlying mechanism is unknown....

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Главные авторы:	Jing Chu, Hong Li, Zhihao Yuan, Wenyu Zhou, Yang Yu, Yonghao Yu
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2023-08-01
Серии:	Brain and Behavior
Предметы:	acetaminophen ferroptosis FSP1 GPX4 sepsis‐associated encephalopathy
Online-ссылка:	https://doi.org/10.1002/brb3.3145
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