Transition Mutations in the hTERT Promoter Are Unrelated to Potential i-motif Formation in the C-Rich Strand

Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients. Cytosine-to-thymine (C-to-T) transition mutations (C250T or C228T) in the <i>hTERT</i> promoter create binding sites for transcription factors, whi...

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Detalhes bibliográficos

Principais autores:	James W. Conrad, Mark L. Sowers, Dianne Y. Yap, Ellie Cherryhomes, B. Montgomery Pettitt, Kamil Khanipov, Lawrence C. Sowers
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-08-01
Colecção:	Biomolecules
Assuntos:	telomere telomerase cytosine deamination transition mutation quadruplex
Acesso em linha:	https://www.mdpi.com/2218-273X/13/9/1308
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