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Acid-base and lipophilic properties of peptide nucleic acid derivatives

The first combined experimental and theoretical study on the ionization and lipophilic properties of peptide nucleic acid (PNA) derivatives, including eleven PNA monomers and two PNA decamers, is described. The acidity constants (pKa) of individual acidic and basic centers of PNA monomers were measu...

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Principais autores: Pramod Thakare, Francesca Vasile, Maura Vallaro, Sonja Visentin, Giulia Caron, Emanuela Licandro, Silvia Cauteruccio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-10-01
coleção:Journal of Pharmaceutical Analysis
Assuntos:
Peptide nucleic acids
Ionization properties
Potentiometric pH titration
Immobilized artificial membrane chromatography
Lipophilicity
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2095177920310273
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