Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic

Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction, while PERK phosphorylates eIF2α. We engineered a potent small molecule, I...

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Autors principals:	Aaron S Mendez, Jennifer Alfaro, Marisol A Morales-Soto, Arvin C Dar, Emma McCullagh, Katja Gotthardt, Han Li, Diego Acosta-Alvear, Carmela Sidrauski, Alexei V Korennykh, Sebastian Bernales, Kevan M Shokat, Peter Walter
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2015-05-01
Col·lecció:	eLife
Matèries:	protein kinase human cell IPA IRE1 PERK
Accés en línia:	https://elifesciences.org/articles/05434
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