Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

ABSTRACT Brain metastasis is a major cause of mortality in advanced lung adenocarcinoma (LUAD). Accumulating evidence indicates that dysregulated lipid metabolism contributes to metastatic colonization; however, how cholesterol functions as a downstream effector within established lipid‐metabolic pr...

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主要な著者:	Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2026-03-01
シリーズ:	Advanced Science
主題:	brain metastasis cholesterol EGFR glycolytic reprogramming lung adenocarcinoma
オンライン･アクセス:	https://doi.org/10.1002/advs.73843
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