Facile Synthesis of Some Coumarin Derivatives and Their Cytotoxicity through VEGFR2 and Topoisomerase II Inhibition

Novel semisynthetic coumarin derivatives were synthesized to be developed as chemotherapeutic anticancer agents through topoisomerase II, VEGFR2 inhibition that leads to apoptotic cancer cell death. The coumarin amino acids and dipeptides derivatives were prepared by the reaction of coumarin-3-carbo...

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Бібліографічні деталі
Автори:	Mohamed S. Gomaa, Ibrahim A. I. Ali, Gaber El Enany, El Sayed H. El Ashry, Samir M. El Rayes, Walid Fathalla, Abdulghany H. A. Ahmed, Samar A. Abubshait, Haya A. Abubshait, Mohamed S. Nafie
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2022-11-01
Серія:	Molecules
Предмети:	amino acids coumarin DCC coupling dipeptides VEGFR2 topoisomerase II
Онлайн доступ:	https://www.mdpi.com/1420-3049/27/23/8279
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Facile Synthesis of Some Coumarin Derivatives and Their Cytotoxicity through VEGFR2 and Topoisomerase II Inhibition

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