DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells

Abstract Pluripotent stem cells possess a unique nuclear architecture characterized by a larger nucleus and more open chromatin, which underpins their ability to self-renew and differentiate. Here, we show that the nucleolus-specific RNA helicase DDX18 is essential for maintaining the pluripotency o...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Xianle Shi, Yanjing Li, Hongwei Zhou, Xiukun Hou, Jihong Yang, Vikas Malik, Francesco Faiola, Junjun Ding, Xichen Bao, Miha Modic, Weiyu Zhang, Lingyi Chen, Syed Raza Mahmood, Effie Apostolou, Feng-Chun Yang, Mingjiang Xu, Wei Xie, Xin Huang, Yong Chen, Jianlong Wang
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2024-12-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-024-55054-8
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!