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Hyaluronic acid-alendronate conjugate: A macromolecular drug delivery system for intra-articular treatment of osteoarthritis

Objective: Osteoarthritis (OA) is a painful degenerative disease of the whole joint structure, including articular cartilage, synovial fluid, and subchondral bone. Hyaluronic acid (HA), an anionic non-sulfated glycosaminoglycan, is commonly used for intra-articular (IA) treatment in OA, while bispho...

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Principais autores: Stefano Pluda, Riccardo Beninatto, Matteo Soato, Carlo Barbera, Alba di Lucia, Lidia Fassina, Filippo Gatti, Cristian Guarise, Devis Galesso, Mauro Pavan
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021-06-01
Series:Osteoarthritis and Cartilage Open
Assuntos:
Hyaluronan
Bisphosphonate
Osteoarthritis
Intra-articular
Alendronate
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2665913121000224
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