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Phase 1 study of chidamide in combination with venetoclax, azacitidine, aclarubicin, cytarabine and G-CSF for refractory/relapsed acute myeloid leukemia: clinical safety, efficacy, and correlative analysis

BackgroundRelapsed or refractory AML (R/R-AML) remains a particularly adverse population necessitating improved therapeutic strategies. In this phase 1 study, we evaluated the efficacy and safety of chidamide, azacitidine, cytarabine, aclarubicin and granulocyte colony-stimulating factor (CACAG) in...

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Principais autores: Yanan Wen, Jingjing Yang, Xiawei Zhang, Qingyang Liu, Wenjing Gao, Lili Dong, Weijia Zhao, Sai Huang, Daihong Liu, Yu Jing, Liping Dou
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-12-01
Serier:Frontiers in Immunology
Fag:
acute myeloid leukemia
relapsed
refractory
salvage regimen
venetoclax
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1698710/full
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