Spatial and Temporal Heterogeneity of Tumor-Infiltrating Lymphocytes in Advanced Urothelial Cancer

Checkpoint inhibitors targeting PD-(L)1 induce objective responses in 20% of patients with metastatic urothelial cancer (UC). CD8+ T cell infiltration has been proposed as a putative biomarker for response to checkpoint inhibitors. Nevertheless, data on spatial and temporal heterogeneity of tumor-in...

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Egile Nagusiak:	Sandra van Wilpe, Mark A. J. Gorris, Lieke L. van der Woude, Shabaz Sultan, Rutger H. T. Koornstra, Antoine G. van der Heijden, Winald R. Gerritsen, Michiel Simons, I. Jolanda M. de Vries, Niven Mehra
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2022-01-01
Saila:	Frontiers in Immunology
Gaiak:	urothelial cancer tumor-infiltrating lymphocytes spatial heterogeneity longitudinal changes biomarkers
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.802877/full
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