Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours

Testicular germ cell tumours (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift towards DNA hypermethylation mediates cisplatin resistance in TGCT cells, although there is little direct evidence to support thi...

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Detalhes bibliográficos

Principais autores:	Zeeshan Fazal, Ratnakar Singh, Fang Fang, Emmanuel Bikorimana, Hannah Baldwin, Andrea Corbet, Megan Tomlin, Cliff Yerby, Nabil Adra, Costantine Albany, Sarah Lee, Sarah J. Freemantle, Kenneth P Nephew, Brock C Christensen, Michael J. Spinella
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2021-10-01
coleção:	Epigenetics
Assuntos:	cisplatin testicular germ cell tumour dna methylation chemoresistance
Acesso em linha:	http://dx.doi.org/10.1080/15592294.2020.1834926
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