Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signaling

Abstract Background Angiogenesis and osteogenesis are closely interrelated. The interaction between endothelial and bone-forming cells, such as osteoblasts, is crucial for normal bone development and repair. Juxtacrine and paracrine mechanisms play key roles in cell differentiation towards the osteo...

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Detalhes bibliográficos

Principais autores:	Daria Perepletchikova, Polina Kuchur, Liubov Basovich, Irina Khvorova, Arseniy Lobov, Kseniia Azarkina, Nikolay Aksenov, Svetlana Bozhkova, Vitaliy Karelkin, Anna Malashicheva
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-02-01
coleção:	Cell Communication and Signaling
Assuntos:	Endothelial cells Osteoblasts Osteogenic differentiation Notch signaling Co-culture
Acesso em linha:	https://doi.org/10.1186/s12964-025-02096-0
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