Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer

Abstract Background Endometrial cancer (EC) is a major gynecological cancer with increasing incidence. It comprises four molecular subtypes with differing etiology, prognoses, and responses to chemotherapy. In the future, clinical trials testing new single agents or combination therapies will be tar...

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主要な著者:	Vanessa F. Bonazzi, Olga Kondrashova, Deborah Smith, Katia Nones, Asmerom T. Sengal, Robert Ju, Leisl M. Packer, Lambros T. Koufariotis, Stephen H. Kazakoff, Aimee L. Davidson, Priya Ramarao-Milne, Vanessa Lakis, Felicity Newell, Rebecca Rogers, Claire Davies, James Nicklin, Andrea Garrett, Naven Chetty, Lewis Perrin, John V. Pearson, Ann-Marie Patch, Nicola Waddell, Pamela M. Pollock
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2022-01-01
シリーズ:	Genome Medicine
主題:	Endometrial cancer Patient-derived xenografts Genomic characterization Mutational signatures Genomic scarring Tumor heterogeneity
オンライン･アクセス:	https://doi.org/10.1186/s13073-021-00990-z
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