Pharmacokinetics of Dolutegravir, nucleoside analogues, and intracellular metabolites using plasma separation cards: A comparative analysis with traditional sampling methods in healthy volunteers.

<h4>Objectives</h4>Adherence to antiretroviral therapy is essential for achieving viral suppression. Plasma separation cards (HemaSep; HS-DBS) provide advantages for pharmacokinetic (PK) analysis and adherence monitoring, including simplified sample collection. This study compared the PK of dolutegr...

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Автори:	Beth Thompson, Laura J Else, Laura Dickinson, Stacey Edick, Ashley Zyhowski, Ken Ho, Leslie Meyn, Sujan Dilly-Penchala, Victoria Shaw, Ian McGowan, Saye Khoo, Rhonda M Brand
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Public Library of Science (PLoS) 2026-01-01
Серія:	PLoS ONE
Онлайн доступ:	https://doi.org/10.1371/journal.pone.0341252
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