Mitochondrial Transport and Turnover in the Pathogenesis of Amyotrophic Lateral Sclerosis

Neurons are high-energy consuming cells, heavily dependent on mitochondria for ATP generation and calcium buffering. These mitochondrial functions are particularly critical at specific cellular sites, where ionic currents impose a large energetic burden, such as at synapses. The highly polarized nat...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Veronica Granatiero, Giovanni Manfredi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2019-05-01
Schriftenreihe:	Biology
Schlagworte:	mitochondria ALS axonal transport mitophagy SOD1 Miro1 PINK1 Parkin
Online-Zugang:	https://www.mdpi.com/2079-7737/8/2/36
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