Functional Role of AveC Residues Ser138 and Ala139 for Avermectin and Doramectin Biosynthesis in <i>Streptomyces avermitilis</i>
<b>Background:</b> Doramectin (CHC-B1) is an excellent antiparasitic drug produced by feeding cyclohexanecarboxylic acid (CHC) to <i>Streptomyces</i><i>avermitilis bkd<sup>−</sup></i> mutants. AveC, a bifunctional enzyme encoded by <i>aveC</i> (<i>sav_0940</i>), catalyzes the stereospecific spiroket...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI AG
2026-06-01
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| Col·lecció: | Metabolites |
| Matèries: | |
| Accés en línia: | https://www.mdpi.com/2218-1989/16/6/409 |
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