Resolving hot spots in the C-terminal dimerization domain that determine the stability of the molecular chaperone Hsp90.

Human heat shock protein of 90 kDa (hHsp90) is a homodimer that has an essential role in facilitating malignant transformation at the molecular level. Inhibiting hHsp90 function is a validated approach for treating different types of tumors. Inhibiting the dimerization of hHsp90 via its C-terminal d...

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Үндсэн зохиолчид:	Emanuele Ciglia, Janina Vergin, Sven Reimann, Sander H J Smits, Lutz Schmitt, Georg Groth, Holger Gohlke
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Public Library of Science (PLoS) 2014-01-01
Цуврал:	PLoS ONE
Онлайн хандалт:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096031&type=printable
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!