Resolving hot spots in the C-terminal dimerization domain that determine the stability of the molecular chaperone Hsp90.
Human heat shock protein of 90 kDa (hHsp90) is a homodimer that has an essential role in facilitating malignant transformation at the molecular level. Inhibiting hHsp90 function is a validated approach for treating different types of tumors. Inhibiting the dimerization of hHsp90 via its C-terminal d...
Zapisane w:
| Główni autorzy: | , , , , , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2014-01-01
|
| Seria: | PLoS ONE |
| Dostęp online: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096031&type=printable |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|