Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

Abstract A C9orf72 repeat expansion is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis. One of the suggested pathomechanisms is toxicity from dipeptide repeat proteins (DPRs), which are generated via unconventional translation of sense and antisense r...

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Ngā kaituhi matua:	Annelies Quaegebeur, Idoia Glaria, Tammaryn Lashley, Adrian M. Isaacs
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2020-11-01
Rangatū:	Acta Neuropathologica Communications
Ngā marau:	Frontotemporal dementia Frontotemporal lobar degeneration C9orf72 mutation Dipeptide repeat proteins Poly-GR Solubility
Urunga tuihono:	http://link.springer.com/article/10.1186/s40478-020-01036-y
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