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Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and response in vivo

Interleukin-2 (IL-2), along with T-cell receptor (TCR) signaling, are required to control regulatory T cell (Treg) homeostasis and function in vivo. Due to the heightened sensitivity to IL-2, Tregs retain the ability to respond to low-dose or attenuated forms of IL-2, as currently being developed fo...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Shining Ma, Michelle So, Aazam Ghelani, Rohith Srivas, Anupama Sahoo, Robyn Hall, Wenjun Liu, Hao Wu, Sherman Yu, Shiping Lu, Elly Song, Taryn Cariaga, Marcus Soto, Hong Zhou, Chi-Ming Li, Ashutosh Chaudhry, Xin Luo, Sue J. Sohn
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2023-09-01
Rangatū:Frontiers in Immunology
Ngā marau:
regulatory T cell (Treg)
interleukin-2 (IL-2)
IL-2 therapy
cytokine
T cell receptor (TCR)
in vivo
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1257652/full
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