Impaired neutrophil-mediated cell death drives Ewing’s Sarcoma in the background of Down syndrome

IntroductionEwing Sarcoma (EWS) has been reported in seven children with Down syndrome (DS). To date, a detailed assessment of this solid tumour in DS patients is yet to be made.MethodsHere, we characterise a chemo-resistant mediastinal EWS in a 2-year-old DS child, the youngest ever reported case,...

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Main Authors:	Serena Peirone, Elisa Tirtei, Anna Campello, Caterina Parlato, Simonetta Guarrera, Katia Mareschi, Elena Marini, Sebastian Dorin Asaftei, Luca Bertero, Mauro Papotti, Francesca Priante, Sarah Perrone, Matteo Cereda, Franca Fagioli
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2024-10-01
Series:	Frontiers in Oncology
Subjects:	Ewing Sarcoma Down syndrome paediatric bone sarcoma genomics transcriptomics neutrophils
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1429833/full
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