MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis.In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for...

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Главные авторы:	Elena Favaro, Anassuya Ramachandran, Robert McCormick, Harriet Gee, Christine Blancher, Meredith Crosby, Cecilia Devlin, Christopher Blick, Francesca Buffa, Ji-Liang Li, Borivoj Vojnovic, Ricardo Pires das Neves, Peter Glazer, Francisco Iborra, Mircea Ivan, Jiannis Ragoussis, Adrian L Harris
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2010-04-01
Серии:	PLoS ONE
Online-ссылка:	http://europepmc.org/articles/PMC2859946?pdf=render
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