Central 5-HTergic hyperactivity induces myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-like pathophysiology

Abstract Objectives Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a significant medical challenge, with no indisputable pathophysiological mechanism identified to date. Methods Based on clinical clues, we hypothesized that 5-hydroxytryptamine (5-HT) hyperactivation is implicated in...

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Autori principali:	Jin-Seok Lee, Ji-Yun Kang, Samuel-Young Park, Seung-Ju Hwang, Sung-Jin Bae, Chang-Gue Son
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-01-01
Serie:	Journal of Translational Medicine
Soggetti:	Myalgic encephalomyelitis/chronic fatigue syndrome Fatigue, serotonin 5-HT1A receptor Desensitization Hypocortisolism
Accesso online:	https://doi.org/10.1186/s12967-023-04808-x
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