Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs

Summary: Macrophages are central innate immune cells whose function declines with age. The molecular mechanisms underlying age-related changes remain poorly understood, particularly in human macrophages. We report a substantial reduction in phagocytosis, migration, and chemotaxis in human monocyte-d...

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Hlavní autoři:	Charlotte E. Moss, Simon A. Johnston, Joshua V. Kimble, Martha Clements, Veryan Codd, Stephen Hamby, Alison H. Goodall, Sumeet Deshmukh, Ian Sudbery, Daniel Coca, Heather L. Wilson, Endre Kiss-Toth
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-04-01
Edice:	Cell Reports
Témata:	CP: Immunology
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124724004017
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