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A High-Affinity Nanobody Selectively Recognizing KPC-2/KPC-3: Biochemical and Structural Insights

Carbapenemase-producing bacteria, particularly those expressing the KPC-3 variant, pose a critical global health threat due to their resistance to nearly all β-lactam antibiotics, including carbapenems. Rapid and reliable detection tools are urgently needed to improve infection control and guide pat...

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Autori principali: Emna Hamdi, Oussema Khamessi, Alessandra Piccirilli, Sayda Dhaouadi, Sinda Zarrouk, Fabrizia Brisdelli, Hafedh Dabbek, Mohamed Hedi Saihi, Balkiss Bouhaouala-Zahar, Rahma Ben Abderrazek, Mariagrazia Perilli
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2026-02-01
Serie:Biomolecules
Soggetti:
carbapenem resistance
KPC-3
KPC-2
β-lactamases
nanobodies (VHHs)
β-lactamase detection
Accesso online:https://www.mdpi.com/2218-273X/16/3/369
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