DNA damage in homocystinuria: 8-oxo‑,8‑dihydro‑2’-deoxyguanosine levels in cystathionine-β-synthase deficient patients and the in vitro protective effect of N-acetyl‑L‑cysteine

Introduction: Homocysteine (Hcy) tissue accumulation occurs in a metabolic disease characterized biochemically by cystathionine β-synthase (CBS) deficiency and clinically by mental retardation, vascular problems, and skeletal abnormalities. Previous studies indicate the occurrence of DNA damage seco...

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Autors principals:	Camila Simioni Vanzin, Caroline Paula Mescka, Bruna Donida, Desirèe Padilha Marchetti, Carlos Eduardo Jacques, Tatiane Hauschild, Jéssica Lamberty Faverzani, Marion Deon, Dinara Moura, Jenifer Saffi, Daniella de Moura Coelho, Moacir Wajner, Angela T.S. Wyse, Carmen Regla Vargas
Format:	Artigo
Idioma:	Inglês
Publicat:	Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS) 2018-04-01
Col·lecció:	Clinical and Biomedical Research
Matèries:	Cystathionine-β-synthase deficiency oxidative stress 8-oxo-7,8-dihydro- 2’-deoxyguanosine homocysteine DNA damage N-acetyl-L-cysteine
Accés en línia:	http://seer.ufrgs.br/hcpa/article/view/76977
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