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Dysregulated competitive splicing between circular and linear RNAs characterizes hepatocellular carcinoma tumorigenesis and recurrence

Abstract Hepatocellular carcinoma (HCC) remains a global health challenge with a high recurrence rate, highlighting the need to decipher its underlying molecular mechanisms. While circular RNAs (circRNAs) are known to regulate gene expression, the landscape of competitive splicing—the dynamic balanc...

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Principais autores: Sunlu Jiang, Ning Cui, Lei Nie, Jian Shen, Xianmin Zhu, Hong Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-05-01
Serier:Biology Direct
Fag:
Hepatocellular carcinoma
circRNA
Alternative splicing
Competitive splicing
Tumor recurrence
Online adgang:https://doi.org/10.1186/s13062-026-00829-w
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