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Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum

Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein...

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Principais autores: Daniel Torres-Mendoza, Lorena M. Coronado, Laura M. Pineda, Héctor M. Guzmán, Pieter C. Dorrestein, Carmenza Spadafora, Marcelino Gutiérrez
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-08-01
Serier:Molecules
Fag:
Bacillus
surfactins
pumilacidins
coral-associated bacteria
P. falciparum
apoptosis
Online adgang:http://www.mdpi.com/1420-3049/23/9/2179
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