β-elemene enhances the efficacy of PD-L1 inhibitor in lung cancer by reprogramming tumor-associated macrophages to M1 phenotype via suppressing FLT1/PI3K/AKT signaling

Abstract Immune checkpoint inhibitors (ICI), epitomized by PD-1/PD-L1 antibodies, have ushered in a new era in lung cancer treatment. However, ICI monotherapy is only applicable to a small subset of patients with high PD-L1 expression, while most patients with low expression require combination ther...

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Autori principali:	Jianmin Wang, Yongxin Yu, Fenglin Lin, Hang Wang, Weiqi Nian
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2026-05-01
Serie:	Cancer Immunology, Immunotherapy
Soggetti:	β-elemene PD-L1 inhibitor tumor-associated macrophages FLT1 PI3K/AKT pathway
Accesso online:	https://doi.org/10.1007/s00262-026-04386-z
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