CoCoA-diff: counterfactual inference for single-cell gene expression analysis
Abstract Finding a causal gene is a fundamental problem in genomic medicine. We present a causal inference framework, CoCoA-diff, that prioritizes disease genes by adjusting confounders without prior knowledge of control variables in single-cell RNA-seq data. We demonstrate that our method substanti...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BMC
2021-08-01
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| Seri Bilgileri: | Genome Biology |
| Konular: | |
| Online Erişim: | https://doi.org/10.1186/s13059-021-02438-4 |
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