An oncostatin M receptor and chloride intracellular channel 1 crosstalk drives key oncogenic pathways in glioblastoma

Abstract Oncostatin M receptor (OSMR) plays diverse roles in several human malignancies, including brain, breast, and pancreatic cancer. In glioblastoma (GB), OSMR orchestrates a feedforward signaling mechanism with the truncated active mutant of epidermal growth factor receptor (EGFR), the EGFRvIII...

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Bibliografische Detailangaben

Hauptverfasser:	Amir Hossein Mansourabadi, Dianbo Qu, Francesca Cianci, Jamie Snider, Kamaldeep Randhawa, Laura Raco, Max Kotlyar, Mohammad Al Ayach, Guido Rey, Shridhar Sanghvi, Mark Abovsky, Harpreet Singh, H. Artee Luchman, Dylan Burger, Janusz Rak, Vahab D. Soleimani, Igor Jurisica, Igor Stagljar, Michele Mazzanti, Arezu Jahani-Asl
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2026-05-01
Schriftenreihe:	Signal Transduction and Targeted Therapy
Online-Zugang:	https://doi.org/10.1038/s41392-026-02723-3
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