Drug Resistance Mechanism of M46I-Mutation-Induced Saquinavir Resistance in HIV-1 Protease Using Molecular Dynamics Simulation and Binding Energy Calculation

Drug-resistance-associated mutation in essential proteins of the viral life cycle is a major concern in anti-retroviral therapy. M46I, a non-active site mutation in HIV-1 protease has been clinically associated with saquinavir resistance in HIV patients. A 100 ns molecular dynamics (MD) simulation a...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Nilottam Rana, Atul Kumar Singh, Mohd Shuaib, Sanjay Gupta, Mahmoud M. Habiballah, Mustfa F. Alkhanani, Shafiul Haque, Mohd Salim Reshi, Shashank Kumar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-03-01
coleção:	Viruses
Assuntos:	drug resistance saquinavir M46I mutation HIV-1 protease anti-retroviral therapy
Acesso em linha:	https://www.mdpi.com/1999-4915/14/4/697
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!